OverviewResultsDownloadReferencesLinks
2009,2008 2007 2006 2005 before2005

2009, 2008



Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study

Dirk Vlasselaers, Ilse Milants, Lars Desmet, Pieter J Wouters, Ilse Vanhorebeek, Ingeborg van den Heuvel, Dieter Mesotten, Michael P Casaer, Geert Meyfroidt, Catherine Ingels, Jan Muller, Sophie Van Cromphaut, Miet Schetz, Greet Van den Berghe

The Lancet Published online,

January 27, 2009 DOI:10.1016/S0140-6736(09)60044-1

Publication




A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans

R. Schaller , F. Feichtner, H. Köhler, M.Bodenlenz, J. Plank, A. Wutte, J.K. Mader, M. Ellmerer, R. Hellmich, H. Wedig, R. Hainisch, T.R. Pieber, L. Schaupp

Biosensors and Bioelectronics 24(2009) 2239-2245

Publication




An Automated Discontinuous Venous Blood Sampling System for Ex Vivo Glucose Determination in Humans

Roland Schaller, M.Sc., Franz Feichtner, M.Sc., Hans Köhler, M.Sc., Manfred Bodenlenz, M.Sc., Johannes Plank, M.D., Andrea Wutte, M.Sc., Julia K. Mader, M.D., Martin Ellmerer, Ph.D., Reinhard Hainisch, M.Sc., Thomas R. Pieber, M.D. and Lukas Schaupp, Ph.D

Journal of Diabetes Science and Technology Vol 3, Issue 1, January 2009, 110-116

Publication


Intensive insulin therapy and pentastarch resuscitation in severe sepsis

Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K,German Competence Network Sepsis (SepNet).

N Engl J Med 2008 Jan 10;358(2):125-39

Letter:

CLINICIP Partner Critique regarding Brunkhorst et al.: Plank J, Ellmerer M




Evaluation of a Model Predictive Control Algorithm using Time Variant Sampling to establish Tight Glycemic for Intensive Care Patients

Christoph Pachler, Joahannes Plank, heinz Weinhandl, Ludovic Chassin, Peter Kaufmann, Karl-Heinz Smolle, Thomas R. Pieber, Martin Ellmerer, Roman Hovorka

Intensive Care Medicine


2007



Pilot study to evaluate blood glucose control by a model predictive control algorithm with variable sampling rate vs. routine glucose management protocol in peri- and postoperative periodic in cardiac surgery patients

Roubicek T, Kremen J, Blaha J, Matias M, Kopecky P, Rulisek J, Anderlova K, Bosanka L, Mraz M, Chassin LJ, Hovorka R, Svacina S, Haluzik M

Cas Lek Cesk. 2007;146(11):868-73.Czech.




Blood glucose control by a model predictive control algorithm with variable sampling rate vs. a routine glucose management protocol in cardiac surgery patients: a randomized controlled trial

Roman Hovorka, Jaromir Kremen, Jan Blaha, Michal Matias, Katerina Anderlova, Lenka Bosanska, Tomas Roubicek, Malgorzata E Wilinska, Ludovic J Chassin, Stepan Svacina, and Martin Haluzik

Journal of Clinical Endocrinology & Metabolism

Abstract




Recent progress in analytical instrumentation for glycemic control in diabetic and critically ill patients

Venkata Radhakrishna Kondepati, H.Michael Heise

Analytical and Bioanalytical Chemistry

2007 Jun.;388(3): 545-563. Epub 2007 Mar13.


Tight glycaemic control: a prospective observational study of a computerised decision supported intensive insulin therapy protocol.

Shulman R, Finney SJ, O'sullivan C, Glynne PA, Greene R.

Crit Care. 2007 Jul 10;11(4):R75




Bed-side monitoring of subcutaneous interstitial glucose in healthy volunteers using microdialysis and infrared spectrometry

H. M. Heise, U. Damm, M. Bodenlenz, V.R. Kondepati, G. Köhler, M. Ellmerer

Journal of Biomedical Optics 12(2007): 024004-1 - 12




Neue spektrometrische Messtechniken zur Überwachung von Stoffwechselparametern

H. Michael Heise, Uwe Damma, Venkata R. Kondepati

GIT Labor-Fachzeitschrift 2 (2007): S.94 – 97




Continuous reagent-free bedside monitoring of glucose in biofluids using infrared spectrometry and microdialysis

Uwe Damm, Venkata Radhakrishna Kondepati, H. Michael Heise

Vibrational Spectroscopy 43 (2007): 184 – 192




Subcutaneous Adipose Tissue exerts proinflammatory cytokines after minimal trauma in humans

Pachler C, Ikeoka D, Plank J, Weinhandl H, Suppan M, Mader J, Bodenlenz M, Regittnig W, Mangge H, Pieber TR, Ellmerer M.

American Journal of physiologyEndocrinol Metab. 2007 Sep:293(3):E690-6.




Monitoring blood glucose with microdialysis of interstizial fluid in critically ill children

Vlasselaers D, Schaupp L, van den Heuvel I, Mader J, Bodenlenz M, Suppan M, Wouters P, Ellmerer M, Van den Berghe G.

Clin Chem.2007 Mar: 53(3):536-7.




Optical Sensor for interstitial pH measurements

F.Baldini, A.Giannetti, A. Mencaglia, Nello Carrara

Institute of Applied Physics, CNR, Firenze, Italy

Journal of Biomedical Optics

Accepted

Abstract


2006



Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm vs. routine glucose management protocols in intensive care unit patients: Response to Ligtenberg et al.

Plank J, Blaha J, Cordingley J, Wilinska ME, Chassin LJ, Morgan C, Squire S, Haluzik M, Kremen J, Svacina S, Toller W, Plasnik A, Ellmerer M, Hovorka R, Pieber TR.

Diabetes Care. 2006 Aug:29(8):1987-8. No abstract available.




Automated Glucose Control in the ICU: Effect of Nutritional Protocol and Measurement Error

Wilinska ME, Chassin LJ, Hovorka R

Conf Proc IEEE Eng Med Biol Soc. 2006;1:67-70


Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients.

Van den Berghe G, Wouters PJ, Kesteloot K, Hilleman DE.

Crit Care Med. 2006 Mar;34(3):612-6.




Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients.

Plank J, Blaha J, Cordingley J, Wilinska ME, Chassin LJ, Morgan C, Squire S, Haluzik M, Kremen J, Svacina S, Toller W, Plasnik A, Ellmerer M, Hovorka R, Pieber TR.

Diabetes Care. 2006 Feb;29(2):271-6.

Intensive insulin therapy in the medical ICU.

Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R.

N Engl J Med. 2006 Feb 2;354(5):449-61.



Towards reagent-free blood glucose monitoring using microdialysis and transmission spectrometry

H. Michael Heise, Uwe Damm, Oliver Vogt, Venkata R. Kondepati

Vibrational Spectroscopy 42: 124 – 129 (2006)

Abstract




Infrared transmission spectrometry for the determination of urea in microliter sample volumes of blood plasma dialysates

Venkata Radhakrishna Kondepati, Uwe Damm H. Michael Heise

Applied Spectroscopy 60 (8): 920 – 925 (2006)

Abstract




Clinical evaluation of Alternative Site Glucose Measurement in Patients After Major Cardiac Surgery

Martin Ellmerer, Martin Haluzik, Jan Blaha, Mirek Kremen, Stepan Svacina, Julia Mader, Lukas Schaupp, Johannes Plank, Thomas R. Pieber

Diabetes Care 29:1275-1281, 2006


Towards a feasible algorithm for tight glycaemic control in critically ill patients: asystematic review of the literature

Meijering S, Corstjens AM, Tulleken JE, Meertens JH, Zijlstra JG, Ligtenberg JJ.

Crit Care. 2006 Feb: 10(1):R19. Review.



Hyperglycemia and intensive care patients: An expanding story

Dirk Vlasselaers, Luc Mertens

Pediatric Critical Care Medicine 2006 Jul;7(4):397-398




Continuous oxygen monitoring in subcutaneous adipose tissue using microdialysis

Bizzarri A, Koehler H, Cajlakovic M, et al.

ANALYTICA CHIMICA ACTA 573: 48-56 Sp. Iss. SI JUL 28 2006




Continuous monitoring of metabolites in biofluids relevant for clinical chemistry and biotechnological applications using mid-infrared ATR and transmission spectroscopy

H.M. Heise, U. Damm, V.R. Kondepati, L. Küpper, C. Funke, U. Brunert, D. Ihrig

VDI-Berichte 1959, VDI Verlag, Duesseldorf, pp 27 – 38 (2006)

Abstract




Monitoring of glucose concentration in critical patients, comparing arterial blood glucose concentrations and interstitial glucose concentration measured by microdialysis technique.

Kremen J, Blaha J, Matias M, Anderlova K, Ellmerer M, Plank J, Pieber T, Svacina S, Haluzik M.

Vnitr Lek. 2006 Sep; 52(9):777-81.Czech.


 



Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance.

Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D, Bosanska L, Vokurka M, Svacina S, Haluzik M

Journal of Clinical Endocrinology and Metabolism2006 Nov;91(11);4620-7. Epub 2006 Aug8.




Fiber-optic flow-through sensor for online monitoring of glucose

Pasic A, Koehler H, Schaupp L, et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY 386 (5): 1293-1302 NOV 2006


Infrared transmission spectrometry for the determination of urea in microliter sample volumes of blood plasma dialysates

Venkata Radhakrishna Kondepati, Uwe Damm H. Michael Heise

Applied Spectroscopy 60 (8): 920 – 925 (2006)

Abstract


Time-variant insulin sensitivity in critically ill subjects

Freke R Wink, Malgorzata E Wilinska, Ludovic J Chassin, Martin Haluzik, Jan Blaha, Stepan Svacina, Roman Hovorka

Symposium on System Identification – SYSID 2006

Presented

Abstract


COMPARISON OF DIFFERENT INSULIN PROTOCOLS IN POST-CARDIAC SURGERY PATIENTS

J Blaha, R Hovorka, J Kremen, JJ Cordingley, Squire S, J Plank, M Ellmerer, J Kunstyr, T Kotulak, M Stritesky, M Haluzik

European Journal of Anaesthesiology, Volume 23, Supplement S38, May 2006.


Clinical evaluation of Alternative Site Glucose Measurement in Patients After Major Cardiac Surgery

Martin Ellmerer, Martin Haluzik, Jan Blaha, Mirek Kremen, Stepan Svacina, Julia Mader, Lukas Schaupp, Johannes Plank, Thomas R. Pieber

Diabetes Care 29:1275-1281, 2006


Clinical evaluation of subcutaneous lactate metabolism in critically ill patients critical care medicine

Martin Ellmerer, Martin Haluzik, Jan Blaha, Mirek Kremen, Stepan Svacina, Andreas Plasnik, Dimas Ikeoka, Johannes Plank and Thomas R. Pieber

Diabetes Care


Hyperglycemia and intensive care patients: An expanding story

Dirk Vlasselaers, Luc Mertens

Pediatric Critical Care Medicine 2006 Jul;7(4):397-398


Continuous oxygen monitoring in subcutaneous adipose tissue using microdialysis

Bizzarri A, Koehler H, Cajlakovic M, et al.

ANALYTICA CHIMICA ACTA 573: 48-56 Sp. Iss. SI JUL 28 2006


Continuous monitoring of metabolites in biofluids relevant for clinical chemistry and biotechnological applications using mid-infrared ATR and transmission spectroscopy

H.M. Heise, U. Damm, V.R. Kondepati, L. Küpper, C. Funke, U. Brunert, D. Ihrig

VDI-Berichte 1959, VDI Verlag, Duesseldorf, pp 27 – 38 (2006)

Abstract


Entwicklung von kontinuierlich messenden IR- spectroskopischen Messsystemen für Klinischen Chemie

Diplom thesis: Christian Funke

Fachhochschule Südwestfalen (FB Informatik und Naturwissenschaften)


Increased subcutaneous and epicardial adipose tissue production of proinflammatory

Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D, Bosanska L, Vokurka M, Svacina S, Haluzik M

Journal of Clinical Endocrinology and Metabolism (09-2006)


Fiberoptic hybrid sensor for continuous glucose monitoring

Koehler H, Pasic A, Klimant I, et al.

DIABETOLOGIA 49: 584-585 0960 Suppl. 1 SEP 2006


Fiber-optic flow-through sensor for online monitoring of glucose

Pasic A, Koehler H, Schaupp L, et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY 386 (5): 1293-1302 NOV 2006


2005

Grading system to assess clinical performance of closed-loop glucose control

L. J. Chassin, M. E. Wilinska, R. Hovorka

Diabetes Technology & Therapeuthics


Insulin kinetics in type-1 diabetes: Continuous and bolus delivery of rapid acting insulin

M. E. Wilinska, L. J. Chassin, H. C. Schaller, L. Schaupp, T. R. Pieber, R. Hovorka.

IEEE Trans.Biomed.Eng 52 (1):3-12


Management of diabetes using adaptive control

R. Hovorka

Int.J.Adapt.Control 19 (5):309-326, 2005


Optical chemical and biochemical sensors: new trends

F. Baldini, A. Giannetti Proc.

SPIE 5826, Optical Sensing (4-5 Aprile 2005, Dublin Ireland) 485-496, 2005

Abstract




Clinical analysis: glucose

H.M. Heise, P. Abel

Encyclopedia of Analytical Science, P.J. Worsfold, A. Townshend, C.F. Poole (Eds.), 2nd ed., Elsevier, Oxford, Vol. 2, 152-166 (2005).




Towards reagent-free continuous blood glucose monitoring for the critical care environment using micro-dialysis and infrared spectrometry

O. Vogt, U. Damm, H.M. Heise

Proceedings of IASTED International Conference on Biomedical Engineering (BioMED 2005), Innsbruck, Austria.

Abstract


New trends in biosensors for health care.

F.Baldini

Anal Bioanal Chem.2005Mar;381(5):1003. No abstract available.


Intensive insulin therapy protects the endothelium of critically ill patients

Lise Langouche, Ilse Vanhirebeek, Dirk Vlasselaers, Sarah Vander Perre, Pieter J.Wouters, Kristin Skogstrand, Troels K. Hansen, Greet Van den Berghe

The Journal of Clinical Investigation, Clin Invest.2005 Aug;115(8):2277-86


before2005

Evaluation of glucose controllers in virtual environment: Methodology and sample application

L. J. Chassin, M. E. Wilinska, R. Hovorka

Artif.Intell.Med. 32 (3):171-181


Effect of an intensive glucose management protocol on the mortality of critically ill adult patients.

Krinsley JS.

Mayo Clin Proc. 2004 Aug;79(8):992-1000.

Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials.

Pittas AG, Siegel RD, Lau J.

Divisions of Endocrinology, Diabetes and Metabolism, Tufts-New England Medical Center, Boston, Mass, USA. Arch Intern Med. 2004 Oct 11;164(18):2005-11.

Management of diabetes and hyperglycemia in hospitals.

Stephen Clement, MD, CDE, Susan S. Braithwaite, MD, Michelle F. Magee, MD, CDE, Andrew Ahmann, MD, Elizabeth P. Smith, RN, MS, CANP, CDE, Rebecca G. Schafer, MS, RD, CDE and Irl B. Hirsch, MD on behalf of the Diabetes in Hospitals Writing Committee

Department of Endocrinology, Georgetown University Hospital, Washington, DC 20007, USA. Diabetes Care 27:553-591, 2004.

Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control.

Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P.

Crit. Care Med. 2003 Feb;31(2):359-66

Glucose monitoring with long-term subcutaneous microdialysis in neonates.

Baumeister FA, Rolinski B, Busch R, Emmrich P.

Pediatrics 2001 Nov;108(5):1187-92.

Intensive insulin therapy in the critically ill patients.

Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R.

N Engl J Med. 2001 Nov 8;345(19):1359-67.

Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI Study Group. Diabetes Insulin-Glucose in Acute Myocardial Infarction.

Malmberg K, Ryden L, Hamsten A, Herlitz J, Waldenstrom A, Wedel H.

Eur Heart J. 1996 Sep;17(9):1337-44.

© 2004-07 CLINICIP Consortium
This project was co-funded by the EU through the IST programme under FP6

EU-Logo