| Overview | Results | Download | References | Links |
2009, 2008
 |
 |
Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study
Dirk Vlasselaers, Ilse Milants, Lars Desmet, Pieter J Wouters, Ilse Vanhorebeek, Ingeborg van den Heuvel, Dieter Mesotten, Michael P Casaer, Geert Meyfroidt, Catherine Ingels, Jan Muller, Sophie Van Cromphaut, Miet Schetz, Greet Van den Berghe
The Lancet Published online,
January 27, 2009 DOI:10.1016/S0140-6736(09)60044-1
|
 |
A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans
R. Schaller , F. Feichtner, H. Köhler, M.Bodenlenz, J. Plank, A. Wutte, J.K. Mader, M. Ellmerer, R. Hellmich, H. Wedig, R. Hainisch, T.R. Pieber, L. Schaupp
Biosensors and Bioelectronics 24(2009) 2239-2245
|
 |
An Automated Discontinuous Venous Blood Sampling System for Ex Vivo Glucose Determination in Humans
Roland Schaller, M.Sc., Franz Feichtner, M.Sc., Hans Köhler, M.Sc., Manfred Bodenlenz, M.Sc., Johannes Plank, M.D., Andrea Wutte, M.Sc., Julia K. Mader, M.D., Martin Ellmerer, Ph.D., Reinhard Hainisch, M.Sc., Thomas R. Pieber, M.D. and Lukas Schaupp, Ph.D
Journal of Diabetes Science and Technology Vol 3, Issue 1, January 2009, 110-116
Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K,German Competence Network Sepsis (SepNet).
N Engl J Med 2008 Jan 10;358(2):125-39
Letter:
CLINICIP Partner Critique regarding Brunkhorst et al.: Plank J, Ellmerer M
|
 |
Evaluation of a Model Predictive Control Algorithm using Time Variant Sampling to establish Tight Glycemic for Intensive Care Patients
Christoph Pachler, Joahannes Plank, heinz Weinhandl, Ludovic Chassin, Peter Kaufmann, Karl-Heinz Smolle, Thomas R. Pieber, Martin Ellmerer, Roman Hovorka
Intensive Care Medicine
2007
|
 |
Pilot study to evaluate blood glucose control by a model predictive control algorithm with variable sampling rate vs. routine glucose management protocol in peri- and postoperative periodic in cardiac surgery patients
Roubicek T, Kremen J, Blaha J, Matias M, Kopecky P, Rulisek J, Anderlova K, Bosanka L, Mraz M, Chassin LJ, Hovorka R, Svacina S, Haluzik M
Cas Lek Cesk. 2007;146(11):868-73.Czech.
|
 |
Blood glucose control by a model predictive control algorithm with variable sampling rate vs. a routine glucose management protocol in cardiac surgery patients: a randomized controlled trial
Roman Hovorka, Jaromir Kremen, Jan Blaha, Michal Matias, Katerina Anderlova, Lenka Bosanska, Tomas Roubicek, Malgorzata E Wilinska, Ludovic J Chassin, Stepan Svacina, and Martin Haluzik
Journal of Clinical Endocrinology & Metabolism
|
 |
Recent progress in analytical instrumentation for glycemic control in diabetic and critically ill patients
Venkata Radhakrishna Kondepati, H.Michael Heise
Analytical and Bioanalytical Chemistry
2007 Jun.;388(3): 545-563. Epub 2007 Mar13.
Tight glycaemic control: a prospective observational study of a computerised decision supported intensive insulin therapy protocol.
Shulman R, Finney SJ, O'sullivan C, Glynne PA, Greene R.
Crit Care. 2007 Jul 10;11(4):R75
|
 |
Bed-side monitoring of subcutaneous interstitial glucose in healthy volunteers using microdialysis and infrared spectrometry
H. M. Heise, U. Damm, M. Bodenlenz, V.R. Kondepati, G. Köhler, M. Ellmerer
Journal of Biomedical Optics 12(2007): 024004-1 - 12
|
 |
Neue spektrometrische Messtechniken zur Überwachung von Stoffwechselparametern
H. Michael Heise, Uwe Damma, Venkata R. Kondepati
GIT Labor-Fachzeitschrift 2 (2007): S.94 – 97
|
 |
Continuous reagent-free bedside monitoring of glucose in biofluids using infrared spectrometry and microdialysis
Uwe Damm, Venkata Radhakrishna Kondepati, H. Michael Heise
Vibrational Spectroscopy 43 (2007): 184 – 192
|
 |
Subcutaneous Adipose Tissue exerts proinflammatory cytokines after minimal trauma in humans
Pachler C, Ikeoka D, Plank J, Weinhandl H, Suppan M, Mader J, Bodenlenz M, Regittnig W, Mangge H, Pieber TR, Ellmerer M.
American Journal of physiologyEndocrinol Metab. 2007 Sep:293(3):E690-6.
|
 |
Monitoring blood glucose with microdialysis of interstizial fluid in critically ill children
Vlasselaers D, Schaupp L, van den Heuvel I, Mader J, Bodenlenz M, Suppan M, Wouters P, Ellmerer M, Van den Berghe G.
Clin Chem.2007 Mar: 53(3):536-7.
|
 |
Optical Sensor for interstitial pH measurements
F.Baldini, A.Giannetti, A. Mencaglia, Nello Carrara
Institute of Applied Physics, CNR, Firenze, Italy
Accepted
2006
|
 |
Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm vs. routine glucose management protocols in intensive care unit patients: Response to Ligtenberg et al.
Plank J, Blaha J, Cordingley J, Wilinska ME, Chassin LJ, Morgan C, Squire S, Haluzik M, Kremen J, Svacina S, Toller W, Plasnik A, Ellmerer M, Hovorka R, Pieber TR.
Diabetes Care. 2006 Aug:29(8):1987-8. No abstract available.
|
 |
Automated Glucose Control in the ICU: Effect of Nutritional Protocol and Measurement Error
Wilinska ME, Chassin LJ, Hovorka R
Conf Proc IEEE Eng Med Biol Soc. 2006;1:67-70
Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients.
Van den Berghe G, Wouters PJ, Kesteloot K, Hilleman DE.
Crit Care Med. 2006 Mar;34(3):612-6.
|
 |
Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients.
Plank J, Blaha J, Cordingley J, Wilinska ME, Chassin LJ, Morgan C, Squire S, Haluzik M, Kremen J, Svacina S, Toller W, Plasnik A, Ellmerer M, Hovorka R, Pieber TR.
Diabetes Care. 2006 Feb;29(2):271-6.
Intensive insulin therapy in the medical ICU.
Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R.
N Engl J Med. 2006 Feb 2;354(5):449-61.
|
 |
Towards reagent-free blood glucose monitoring using microdialysis and transmission spectrometry
H. Michael Heise, Uwe Damm, Oliver Vogt, Venkata R. Kondepati
Vibrational Spectroscopy 42: 124 – 129 (2006)
|
 |
Infrared transmission spectrometry for the determination of urea in microliter sample volumes of blood plasma dialysates
Venkata Radhakrishna Kondepati, Uwe Damm H. Michael Heise
Applied Spectroscopy 60 (8): 920 – 925 (2006)
|
 |
Clinical evaluation of Alternative Site Glucose Measurement in Patients After Major Cardiac Surgery
Martin Ellmerer, Martin Haluzik, Jan Blaha, Mirek Kremen, Stepan Svacina, Julia Mader, Lukas Schaupp, Johannes Plank, Thomas R. Pieber
Diabetes Care 29:1275-1281, 2006
Towards a feasible algorithm for tight glycaemic control in critically ill patients: asystematic review of the literature
Meijering S, Corstjens AM, Tulleken JE, Meertens JH, Zijlstra JG, Ligtenberg JJ.
Crit Care. 2006 Feb: 10(1):R19. Review.
|
 |
Hyperglycemia and intensive care patients: An expanding story
Dirk Vlasselaers, Luc Mertens
Pediatric Critical Care Medicine 2006 Jul;7(4):397-398
|
 |
Continuous oxygen monitoring in subcutaneous adipose tissue using microdialysis
Bizzarri A, Koehler H, Cajlakovic M, et al.
ANALYTICA CHIMICA ACTA 573: 48-56 Sp. Iss. SI JUL 28 2006
|
 |
Continuous monitoring of metabolites in biofluids relevant for clinical chemistry and biotechnological applications using mid-infrared ATR and transmission spectroscopy
H.M. Heise, U. Damm, V.R. Kondepati, L. Küpper, C. Funke, U. Brunert, D. Ihrig
VDI-Berichte 1959, VDI Verlag, Duesseldorf, pp 27 – 38 (2006)
|
 |
Monitoring of glucose concentration in critical patients, comparing arterial blood glucose concentrations and interstitial glucose concentration measured by microdialysis technique.
Kremen J, Blaha J, Matias M, Anderlova K, Ellmerer M, Plank J, Pieber T, Svacina S, Haluzik M.
Vnitr Lek. 2006 Sep; 52(9):777-81.Czech.
|
 |
Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance.
Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D, Bosanska L, Vokurka M, Svacina S, Haluzik M
Journal of Clinical Endocrinology and Metabolism2006 Nov;91(11);4620-7. Epub 2006 Aug8.
|
 |
Fiber-optic flow-through sensor for online monitoring of glucose
Pasic A, Koehler H, Schaupp L, et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY 386 (5): 1293-1302 NOV 2006
Infrared transmission spectrometry for the determination of urea in microliter sample volumes of blood plasma dialysates
Venkata Radhakrishna Kondepati, Uwe Damm H. Michael Heise
Applied Spectroscopy 60 (8): 920 – 925 (2006)
Time-variant insulin sensitivity in critically ill subjects
Freke R Wink, Malgorzata E Wilinska, Ludovic J Chassin, Martin Haluzik, Jan Blaha, Stepan Svacina, Roman Hovorka
Symposium on System Identification – SYSID 2006
Presented
COMPARISON OF DIFFERENT INSULIN PROTOCOLS IN POST-CARDIAC SURGERY PATIENTS
J Blaha, R Hovorka, J Kremen, JJ Cordingley, Squire S, J Plank, M Ellmerer, J Kunstyr, T Kotulak, M Stritesky, M Haluzik
European Journal of Anaesthesiology, Volume 23, Supplement S38, May 2006.
Clinical evaluation of Alternative Site Glucose Measurement in Patients After Major Cardiac Surgery
Martin Ellmerer, Martin Haluzik, Jan Blaha, Mirek Kremen, Stepan Svacina, Julia Mader, Lukas Schaupp, Johannes Plank, Thomas R. Pieber
Diabetes Care 29:1275-1281, 2006
Clinical evaluation of subcutaneous lactate metabolism in critically ill patients critical care medicine
Martin Ellmerer, Martin Haluzik, Jan Blaha, Mirek Kremen, Stepan Svacina, Andreas Plasnik, Dimas Ikeoka, Johannes Plank and Thomas R. Pieber
Hyperglycemia and intensive care patients: An expanding story
Dirk Vlasselaers, Luc Mertens
Pediatric Critical Care Medicine 2006 Jul;7(4):397-398
Continuous oxygen monitoring in subcutaneous adipose tissue using microdialysis
Bizzarri A, Koehler H, Cajlakovic M, et al.
ANALYTICA CHIMICA ACTA 573: 48-56 Sp. Iss. SI JUL 28 2006
Continuous monitoring of metabolites in biofluids relevant for clinical chemistry and biotechnological applications using mid-infrared ATR and transmission spectroscopy
H.M. Heise, U. Damm, V.R. Kondepati, L. Küpper, C. Funke, U. Brunert, D. Ihrig
VDI-Berichte 1959, VDI Verlag, Duesseldorf, pp 27 – 38 (2006)
Entwicklung von kontinuierlich messenden IR- spectroskopischen Messsystemen für Klinischen Chemie
Diplom thesis: Christian Funke
Fachhochschule Südwestfalen (FB Informatik und Naturwissenschaften)
Increased subcutaneous and epicardial adipose tissue production of proinflammatory
Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D, Bosanska L, Vokurka M, Svacina S, Haluzik M
Journal of Clinical Endocrinology and Metabolism (09-2006)
Fiberoptic hybrid sensor for continuous glucose monitoring
Koehler H, Pasic A, Klimant I, et al.
DIABETOLOGIA 49: 584-585 0960 Suppl. 1 SEP 2006
Fiber-optic flow-through sensor for online monitoring of glucose
Pasic A, Koehler H, Schaupp L, et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY 386 (5): 1293-1302 NOV 2006
2005
Grading system to assess clinical performance of closed-loop glucose control
L. J. Chassin, M. E. Wilinska, R. Hovorka
Diabetes Technology & Therapeuthics
Insulin kinetics in type-1 diabetes: Continuous and bolus delivery of rapid acting insulin
M. E. Wilinska, L. J. Chassin, H. C. Schaller, L. Schaupp, T. R. Pieber, R. Hovorka.
IEEE Trans.Biomed.Eng 52 (1):3-12
Management of diabetes using adaptive control
R. Hovorka
Int.J.Adapt.Control 19 (5):309-326, 2005
Optical chemical and biochemical sensors: new trends
F. Baldini, A. Giannetti Proc.
SPIE 5826, Optical Sensing (4-5 Aprile 2005, Dublin Ireland) 485-496, 2005
|
 |
Clinical analysis: glucose
H.M. Heise, P. Abel
Encyclopedia of Analytical Science, P.J. Worsfold, A. Townshend, C.F. Poole (Eds.), 2nd ed., Elsevier, Oxford, Vol. 2, 152-166 (2005).
|
 |
Towards reagent-free continuous blood glucose monitoring for the critical care environment using micro-dialysis and infrared spectrometry
O. Vogt, U. Damm, H.M. Heise
Proceedings of IASTED International Conference on Biomedical Engineering (BioMED 2005), Innsbruck, Austria.
New trends in biosensors for health care.
F.Baldini
Anal Bioanal Chem.2005Mar;381(5):1003. No abstract available.
Intensive insulin therapy protects the endothelium of critically ill patients
Lise Langouche, Ilse Vanhirebeek, Dirk Vlasselaers, Sarah Vander Perre, Pieter J.Wouters, Kristin Skogstrand, Troels K. Hansen, Greet Van den Berghe
The Journal of Clinical Investigation, Clin Invest.2005 Aug;115(8):2277-86
before2005
Evaluation of glucose controllers in virtual environment: Methodology and sample application
L. J. Chassin, M. E. Wilinska, R. Hovorka
Artif.Intell.Med. 32 (3):171-181
Effect of an intensive glucose management protocol on the mortality of critically ill adult patients.
Krinsley JS.
Mayo Clin Proc. 2004 Aug;79(8):992-1000.
Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials.
Pittas AG, Siegel RD, Lau J.
Divisions of Endocrinology, Diabetes and Metabolism, Tufts-New England Medical Center, Boston, Mass, USA. Arch Intern Med. 2004 Oct 11;164(18):2005-11.
Management of diabetes and hyperglycemia in hospitals.
Stephen Clement, MD, CDE, Susan S. Braithwaite, MD, Michelle F. Magee, MD, CDE, Andrew Ahmann, MD, Elizabeth P. Smith, RN, MS, CANP, CDE, Rebecca G. Schafer, MS, RD, CDE and Irl B. Hirsch, MD on behalf of the Diabetes in Hospitals Writing Committee
Department of Endocrinology, Georgetown University Hospital, Washington, DC 20007, USA. Diabetes Care 27:553-591, 2004.
Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control.
Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P.
Crit. Care Med. 2003 Feb;31(2):359-66
Glucose monitoring with long-term subcutaneous microdialysis in neonates.
Baumeister FA, Rolinski B, Busch R, Emmrich P.
Pediatrics 2001 Nov;108(5):1187-92.
Intensive insulin therapy in the critically ill patients.
Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R.
N Engl J Med. 2001 Nov 8;345(19):1359-67.
Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI Study Group. Diabetes Insulin-Glucose in Acute Myocardial Infarction.
Malmberg K, Ryden L, Hamsten A, Herlitz J, Waldenstrom A, Wedel H.
Eur Heart J. 1996 Sep;17(9):1337-44.
This project was co-funded by the EU through the IST programme under FP6
